If a display has a path that means that it can be retrieved directly by calling a URL as a first class page on your Drupal site. Any items after the path will be passed into the view as arguments. For example, if the path is foo/bar and a user visits http://www.example.com/foo/bar/baz/beta, 'baz' and 'beta' will be given as arguments to the view. These can be handled by adding items to the arguments section.
You may also use placeholders in your path to represent arguments that come in the middle. For example, the path node/%/someview would expect the first argument to be the second part of the path. For example, node/21/someview would have an argument of '21'.
Note: Views 1 used $arg for this kind of thing. $arg is no longer allowed as part of the path. You must use % instead.