Boost is designed for Drupal 6.x served by Apache on any platform.
Drupal's clean URLs MUST be enabled and working properly.
If the cached files and pages must be cleared at their expired time, the cron run for Drupal must be correctly setup to execute more often than, or as often as the cache lifetime you specify in the settings.
Since the static page caching is implemented with mod_rewrite directives, Apache version 1.3 or 2.x with mod_rewrite enabled is required (if Drupal's clean URLs work for you, you're fine; if not, get them working first).
Other web servers, such as Lighttpd, are NOT officially supported at present.
• Lighttpd • Nginx

Path (Drupal Core)

Poormanscron 1.1 or 2.0 if cron configuration is not available on your server.

If enabled [x] Clear all cached pages referenced via CCK with a node... The Node Referrer module is recommended.